Chronic administration of ketamine induces depression in Wistar rat, but does not affect sexual function

    Published on:31st Dec, 2014
    Journal of Young Pharmacists, 2015; 7(2):137-138
    Letters to Editor | doi:10.5530/jyp.2015.2.13

    Sumanta Kumar Goswami, Archana Kossireddi Venkata, Noor Zahra Jaffer, Mohammed Naseeruddin Inamdar

    Department of Pharmacology, Al-Ameen College of Pharmacy, Bangalore, India – 560027


    Schizophrenia is a mental disorder that is characterized by periodic shift in positive symptoms (conceptual disorganization, delusions, hallucinations, hyperactivity, stereotypy behaviour etc.) and negative symptoms (social withdrawal, loss of function, anhedonia, decreased emotional expression, impaired concentration, and diminished social engagement).1,2 Anhedonia in experimental rats is marked by decrease in intracranial self-stimulation, consumption of sucrose solution, and sexual behavior.3 Depression is associated with different degrees of sexual dysfunction and population suffering from sexual dysfunction are frequently depressed.3,4 Read More...,

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