Pharmacology of Recombinant or Genetically Engineered Drugs

    Published on:
    Journal of Young Pharmacists, 2009; 1(2):140-150
    Pharmacology | doi:10.4103/0975-1483.55747

    Kamal Kishore, Pawan Krishan1

    Departments of Pharmacy, M.J.P. Rohilkhand University, Bareilly-243 006, Uttar Pradesh,

    1Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala-147 002, Punjab, India.


    Recombinant technology or genetic engineering is a modern method used for the synthesis of therapeutic agents. The central theme of recombinant technology is the process of “gene cloning” which consists of the production of a deÞ ned fragment of DNA and its propagation and ampliÞ cation in a suitable host cell. Drugs developed by recombinant technology or genetic engineering are known as biologics, biopharmaceuticals, recombinant DNA expressed products, bioengineered, or genetically engineered drugs. A current list of various products developed by recombinant technology includes erythropoietin, coagulation modulators, enzymes, hormones, interferons, interleukins, granulocyte colony-stimulating factors, anti-rheumatoid drugs, and various other agents like TNF, becaplermin, hepatitis-B vaccine, antibodies etc. This article provides general as well as recent pharmacological information on different aspects of recombinant drugs that may be useful for their better understanding by users and health care professionals.

    Key words: Biologics, erythropoietin, interferon, interleukins, insulin, thrombolytic enzymes.