Skin Penetration Enhancement Techniques

    Published on:
    Journal of Young Pharmacists, 2009; 1(2):110-115
    Pharmaceutics | doi:10.4103/0975-1483.55741

    Bharkatiya M, Nema RK

    Department of Pharmaceutics, B.N. College of Pharmacy, Udaipur, India.


    Transdermal drug delivery systems allow delivery of a drug into the systemic circulation via permeation through skin layers at a controlled rate. In addition to the currently marketed formulations, new drugs are being formulated using the transdermal system because of the inherent advantage of administration by this route. It offers a noninvasive route of drug administration, although its applications are limited by low skin permeability. Innovative research exploiting penetration-enhancing strategies, such as iontophoresis, electroporation, microneedles, and sonophoresis, holds promise for the successful use of these drugs as consumer-friendly, transdermal dosage forms in clinical practice. This review outlines promising new technologies involved in enhancing transdermal permeation.

    Key words: Electroporation, iontophoresis, microneedles, penetration, sonophoresis, transdermal.