Ascertaining the Paradigm of Secondary Metabolism Enhancement through Gene Level Modification in Therapeutic Plants

    Published on:November 2019
    Journal of Young Pharmacists, 2019; 11(4):337-343
    Review Article | doi:10.5530/jyp.2019.11.70

    Swati Sinha1, Kajal Sandhu1, Neema Bisht1, Tapan Naliwal1, Ishan Saini2, Prashant Kaushik3*

    1Department of Biotechnology, Kumaun University, Bhimtal Campus, Bhimtal, INDIA.

    2Department of Botany, Kurukshetra University, Kurukshetra, INDIA.

    3Instituto de Conservación y Mejora de la Agrodiversidad Valenciana, Universitat Politècnica de València, Valencia, SPAIN.


    Since ages plants with therapeutic effects are used for curing several human ailments. With the development in modern biotechnological tools, these therapeutic compounds could be overexpressed in the plants. This review aims to compile the valuable information from the examples in the literature, regarding the biotechnological tools those could be useful for the overproduction of health-promoting biochemicals in the medicinal plants. Gene level modification is all about creating improved variety of plants that are highly resistant to pests and pesticides or contain higher levels of nutrients than conventional plants. Plant secondary metabolites constitute an exciting and vital aspect of research, due to their chemical diversity, varied biological functions and pharmacological activities. Gene modification, through Agrobacterium mediated transformation, RNA interference or CRISPER/Cas9, has opened avenues of improvement in medicinal plants and provide an alternative production system of pharmaceutically important secondary metabolites for their commercial exploitation.

    Key words: Gene modification, Agrobacterium, RNA interference, CRISPR/Cas9, Medicinal plants.

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