Nephroprotective Effect of Pterocarpus indicus Willd. Leaves : Observation of Urine Volume, Sodium and Potassium Levels in Gentamicin-induced Rat Model

    Published on:March 2017
    Journal of Young Pharmacists, 2017; 9(1s):S85-S88
    Original Article | doi:10.5530/jyp.2017.1s.21

    Fadlina Chany Saputri1, Zahra Adiyati1, Desy Rasta Waty2

    1Laboratory of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, INDONESIA.

    2Laboratory of Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, INDONESIA.


    Introduction: Kidney disease is a common disease worldwide. The leaves from Pterocarpus indicus Willd. is alternatively applied for prevention therapy of patients with kidney diseases. Objective: The aim of this study to demonstrate the scientific nephroprotective effect of water-boiled P. indicus leaves evaluated from urine volume, sodium and potassium levels. Materials and Methods: Thirty male Sprague-Dawley rats were divided into five treatment groups; group I (control), group II (gentamicin-induced 80 mg/kg i.p from day 15 to 21), and group III to V (induced; variated doses respectively 28.8 mg/kg; 57,6 mg/kg; and 115,2 mg/kg bw which was given for 21 days orally as single doses). Nephroprotective effects were observed as abnormal from levels of urinary volume. Results: Obtained results on sodium and potassium levels show the group given the highest dose (115,2 mg/kg) resulted in decreased sodium levels and increased levels of urinary potassium as well as having a significant difference (p<0,05) to the induction group. Observed 24-hour urine volume, however, did not show any significant signs of nephroprotective effects. Conclusion: It can be concluded that the leaves of P.indicus have potential nephroprotective properties.

    Key words: Pterocarpus indicus, Gentamicin, Potassium, Sodium, Urine volume, Nephroprotective.

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