Effect of Moringa oleifera Leaves Extract Against Hematology and Blood Biochemical Value of Patients with Iron Deficiency Anemia

    Published on:March 2017
    Journal of Young Pharmacists, 2017; 9(1s):S79-S84
    Original Article | doi:10.5530/jyp.2017.1s.20

    Dona Suzana1, Franciscus D. Suyatna2, Azizahwati3, Retnosari Andrajati3, Santi Purna Sari3, Abdul Mun’im4

    1Graduate Program of Herbal Medicine, Faculty of Pharmacy, Universitas Indonesia, Kampus Baru UI Depok, INDONESIA.

    2Department of Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.

    3Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Kampus Baru UI Depok, INDONESIA.

    4Department of Pharmacognosy-Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Kampus Baru UI Depok, INDONESIA.


    Introduction: Approximately (24.8%) the world’s population suffers from anemia and 50% of an anemic case is due to iron deficiency. This study investigated the efficacy of Moringa oleifera L leaves to extract as an iron booster and supplement to help overcome anemia in the community. Methods: It was a randomized, double-blind, placebo-controlled study in anemic women (hemoglobin 8-12g/dL), in which the water extract of moringa leaves was examined as an add-on therapy in the subject treated with ferrous sulfate (200mg/ tablet). Thirty-five women subject of 16-49 years old were divided into 17 of moringa leaves and 18 of control. The extract of moringa leaves of 1400 mg was formulated in capsules and was administrated daily for 3 weeks. Results: The result showed there were significantly increase of mean of hemoglobin (0.794±0.81 g/dL), ferritin (29.378±42.48 ng/mL), MCHC (Mean Corpuscular Haemoglobin Concentration) (2.459±2.86 g/dL), RDW (Red Distribution Wide) (1.4±2.07 %) and decreased of platelets (36529.41±59024.48 /uL). The control groups were significantly increased of mean of the hemoglobin (0.644± 0.83g/dL), erythrocytes (0.475±0.523 Tpt/L), hematocrit (2.189±l4.08 %), MCV (Mean Corpuscular Volume)( 4.756±8.91 fL), MCH (2.183±2.47 pg) dan RDW (2.844±2.80%).The hematocrit (3.14±1.47%), MCH (Mean Corpuscular Hemoglobin) (3.495±1.33 pg), MCHC (3.264±0.96 g/dL) values of moringa leaves were significantly higher whereas the platelets count (55251.63±23404/uL) of moringa leaves were significantly lower (p<0.05) than those of control group. Conclusion: It can be concluded that moringa leaves extract could improve iron deficiency anemia in women.

    Key words: Anemia, Ferrous sulfate, Ferritin, Hematology, Moringa oleifera.

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