Autoimmune Disorders – Immunopathogenesis and Potential Therapies

    Published on:November 2016
    Journal of Young Pharmacists, 2017; 9(1):14-22
    Review Article | doi:10.5530/jyp.2017.9.4
    Authors:

    Sivadas Ganapathy1*, Vaishnavi Vedam2, Vini Rajeev3, Rajeev Arunachalam4

    1Department of Paedodontics and Preventive Dentistry, Asian Institute of Medicine, Science and Technology (AIMST) University, Malaysia.

    2Department of Oral Pathology, Asian Institute of Medicine, Science and Technology (AIMST) University, Malaysia.

    3Department of Prosthodontics, Asian Institute of Medicine, Science and Technology (AIMST) University, Malaysia.

    4Department of Periodontics, Asian Institute of Medicine, Science and Technology (AIMST) University, Malaysia.

    Abstract:

    Autoimmune disorders are formed in the body as an outcome of inappropriate immune response against its own tissues. Failure of this immune system to recognize the body’s normal constituents as “self” will result in inflammation and tissue damage. Several immune based mechanisms form the basis of autoimmune disorders in the body. Management of these lesions is based on the diagnostic criteria, evaluation of clinical and oral manifestation, and laboratory investigations of these lesions. There is currently no definitive cure for all autoimmune disorders, although in rare cases they may disappear on their own. As patients experience temporary remissions in symptoms or progressive worsening, our pharmacological management are targeted only for symptomatic relief and arrest the progression of the lesion. A detailed approach to titles and abstracts of importance in this field on the topic of interest via review and case reports was included. This review article highlights on various immune pathogenic mechanisms and treatment modalities of autoimmune disorders.

    Key Words: Autoimmune disorders, Autoimmunity, Molecular mimicry, Antigen, Auto antibody, Histocompatibility.

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