Licofelone- Novel Analgesic and Anti-Inß ammatory Agent for Osteoarthritis: An Overview

    Published on:
    Journal of Young Pharmacists, 2009; 1(1):67-71
    Pharmaceutical Chemistry | doi:10.4103/0975-1483.51884
    Authors:

    Gaur K, Kori ML, Tyagi LK, Singh V, Nema RK1, Tripathi P2, Sharma CS3

    Geetanjali College of Pharmaceutical Studies, Manwa Kheda, Udaipur, (Rajasthan)

    1S. D. College of Pharmacy and Vocational Studies, Muzaffarnagar, (Uttar Pradesh),

    2Shri RNS Mahavidhyalaya (Pharmacy), Bhind (Madhya Pradesh),

    3Bhupal Noble’s College of Pharmacy, Udaipur, (Rajasthan), India

    Address for correspondence: Mr. Kalpesh Gaur; E-mail: kalpeshgaur@gmail.com

    Abstract:

    Licofelone (2-[6-(4-chlorophenyl)-2, 2-dimethyl-7-phenyl-2, 3-dihydro-1H-pyrrolizin-5-yl] acetic acid) is the Þ rst member of a new class of analgesic and anti-inß ammatory drugs acting by dual mechanism inhibiting both cyclooxygenase (COX) and 5-lipooxygenase (5-LOX). Inhibition of 5-LOX may reduce the gastrointestinal toxicity associated with other non steroidal anti-inß ammatory drugs (NSAIDs), which only inhibit cyclooxygenase (COX). It has been evaluated for the treatment of osteoarthritis (OA), the most common form of arthritis. It has been found to be signiÞ cantly effective in Phase III clinical trials conducted on patients of osteoarthritis. The present review describes the pharmacological and clinical developments of licofelone as a dual inhibitor for COX and 5-LOX.

    Key words: Licofelone, analgesic, anti-inß ammatory.

     

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