Synthesis and Anti-inflammatory Activity of 7-Non-steroidal Anti-inflammatory Drugs Substituted Flavone

    Published on:December 2020
    Journal of Young Pharmacists , 2020; 12(4):299-302
    Original Article | doi:10.5530/jyp.2020.12.81

    Prakash Govindaraman1,*, Mohan S2, Sundararajan N3, Sivasakthi R4, Balachandar S1

    1Department of Pharmaceutical Chemistry, Karpagam College of Pharmacy, Coimbatore, Tamil Nadu, INDIA.

    2Department of Pharmaceutics, Karpagam College of Pharmacy, Coimbatore, Tamil Nadu, INDIA.

    3Department of Pharmacology, Karpagam College of Pharmacy, Coimbatore, Tamil Nadu, INDIA. 4Department of Pharmacy Practice, Karpagam College of Pharmacy, Coimbatore, Tamil Nadu, INDIA.


    Aim: Inflammation shows an important character in illnesses such for example cardiovascular diseases, asthma, malignant and diabetes. Food can guidance different phases of inflammation and can have an important influence on numerous inflammatory illnesses. Increasing scientific suggestion has displayed that polyphenolic compounds, such as flavonoids, which are originate in vegetables, fruits, cocoa or legumes, can have antiinflammatory activity. Current researches prevent enzymes or transcription factors significant for regulatory intermediaries involved in inflammation. Flavonoids are also famous as effective antioxidants with the potential to weaken tissue injury or fibrosis. Subsequently, frequent studies in vivo and in vitro models shows that flavonoids have the prospective to prevent the beginning and development of inflammatory activity. Materials and Methods: In the present research work, a series of flavones merge with Non-steroidal Anti-Inflammatory Drugs were synthesized from resorcinol through Baker- Venkataraman Method, characterized and calculated there in vitro anti-inflammatory activity by protein denaturation technique. Results: The outcome is protein denaturation studies shown that the compound FS found to be most potent anti-inflammatory activity. The percentage inhibitions were 97.66%.

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