The burden of the resistance to the antibiotics increases day by day and there is a high chance that even minor infections can kill patients in future. There is a high resistance to third generation cephalosporins and fluoroquinolones among Acinietobacter baumanni, Escherchia coli, Klebsiella pneumonia and Pseudomonas aeruginosa. The carbapenam resistance is also increasing among these bacteria. The colistin is the drug used in the treatment of carbapenam resistance and the colistin resistance also has increased. CDSCO has restricted the use of higher antibiotics carbapenams class III and IV for resistant infections. The factors influencing antibiotic resistance are many and WHO has recommended strategies to decrease the mortality and morbidity of antibiotic resistance.
Key words: Antibiotics, Resistance, Post-antibiotic era, Irrational, Selfmedication.