Comparison of Bulk and Precipitation Polymerization Method of Synthesis Molecular Imprinted Solid Phase Extraction for Atenolol using Methacrylic Acid

    Published on:January 2019
    Journal of Young Pharmacists, 2019; 11(1):12-16
    Original Article | doi:10.5530/jyp.2019.11.3
    Authors:

    Rimadani Pratiwi, Sandra Megantara, Driyanti Rahayu, Indraswari Pitaloka, Aliya Nur Hasanah*

    Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor 45363, INDONESIA.

    Abstract:

    Objective: Atenolol is one of beta-blocker are prohibited as doping based on World Anti-Doping Agency (WADA). The purpose of this study was to the synthesis of molecular imprinted polymer (MIP) for extraction of atenolol from the sample. Method: This research compared the two of the method, bulk and precipitation polymerization. The MIP was successfully prepared from methacrylic acid as a functional monomer, ethyleneglycoldimethacrylate as a crosslinker, benzoyl peroxide as an initiator, butanol as a porogenic solvent with atenolol as a template molecule. Result: The result showed that the bulk polymerization method produces sorbents that have good adsorption capacity and small particle compare to the precipitation polymerization. Both methods were selective for atenolol. Conclusion: Generally, the MIP solid phase extraction is an alternative method for extraction atenolol from the sample.

    Key words: Atenolol, Molecular Imprinted Polymer, Solid Phase Extraction.

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