Antioxydant and Endotheliotropic Properties 4-Hydroxy-3,5-Di-Tret-Butyl Cinnamic Acid under Conditions of Experimental Brain Ischemia

    Published on:March 2018
    Journal of Young Pharmacists, 2018; 10(2):193-196
    Original Article | doi:10.5530/jyp.2018.10.43
    Authors:

    Pozdnyakov DI*, Voronkov AV, Zolotych DS, Arlt AV

    Pyatigorsk Medical and Pharmaceutical Institute, A Branch of Volgograd State Medical University, Pyatigorsk, RUSSIA.

    Abstract:

    Objective: To assess the effect of 4-hydroxy-3,5-di-tret-butyl cinnamic acid on the state of endothelial function under conditions of experimental cerebral ischemia. Materials and Methods: Antioxidant properties of 4-hydroxy-3,5-di-tret-butyl cinnamic acid and the effect of this compound on NO-synthase system activity and ADMA concentration were evaluated. Results: As a result, it has been found that the use of 4-hydroxy-3,5-di-tretbutyl cinnamic acid promotes reduction activity of catalase, glutathione peroxidase, superoxide dismutase and a decrease in the concentration of MDA and DC. In addition, the ability to modulate NO synthase system activity was established for this compound: an increase in eNOS activity by 114.2% (p <0.05), decrease activity of nNOS and iNOS by 60.6% (p <0.05) and 61.9% (p <0.05), respectively, decrease concentration of ADMA by 83.9% (p <0.05). Conclusion: The results of the conducted researches it is established that 4-hydroxy-3,5-di-tret-butyl cinnamic acid has antioxidant and NOS - regulating effect.

    Key words: Experimental ischemic stroke, Cinnamic acid derivatives, Antioxidants, Endothelium

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