Objective: Ondansetron is an anti-emetic drug which is insoluble in water; hence the drug may be slowly or incompletely dissolves in the gastrointestinal tract. So the rate of dissolution and therefore its bioavailability is 60%. The present study is to formulate and evaluate fast disintegrating tablets of ondansetron by direct compression method employing natural polymers and modified starches as super disintegrating agents Methods: In the present study an attempt has been made to prepare fast Disintegrating tablets of Linseed, Isapgol, Sodium starch glycolate and Pre gelatinized starch used in the level of addition to increase the rate of drug release from dosage form to increase the dissolution rate. Direct Compression method was used to formulate the tablets. Results: All the formulations were showed the acceptable flow properties and the pre compression parameters like Bulk density, Tapped density and Carr’s compressibility index and Hausner ratio. The post compression parameters like Weight variation, friability, hardness, disintegration, wetting time, water absorption ration, and In vitro dissolution profile values were found to be within specified limits. FTIR Studies shows no interaction between Drug and excipients. Conclusion: From the data obtained, it is observed from the formulation containing Isapghol in Formulation F9, shows Disintegration time in 12 seconds and the Percentage drug release is of 99.10% at the end of 30 min which satisfied all the tablet evaluation parameters for fast disintegrating tablet.
Key words: Direct Compression, Ondansetron, Modified Starches, Natural Polymers, Fast Disintegrating Tablets.