Application of Ionic Liquid as a Green Solvent for Polyphenolics Content Extraction of Peperomia pellucida (L) Kunth Herb

    Published on: October 2017
    Journal of Young Pharmacists, 2017; 9(4):486-490
    Original Article | doi:10.5530/jyp.2017.9.95
    Authors:

    Islamudin Ahmad1,2*, Arry Yanuar2, Kamarza Mulia3, Abdul Mun’im2*

    1Department of Pharmaceutical Sciences, Faculty of Pharmacy, Mulawarman University, Samarinda 75119 East Kalimantan, INDONESIA.

    2Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Indonesia, Depok 16424 West Java, INDONESIA.

    3Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok 16424 West Java, INDONESIA.

    Abstract:

    Objective: The aims of the study was to explore the application effect of ionic liquid as a green solvent in the polyphenolics content extraction from Peperomia pellucida (L.) Kunth herbs using 1-butyl-3-methyl imidazolium bromide ([BMIM]Br) and 1-butyl-3-methyl imidazolium chloride ([BMIM]Cl). Methods: The polyphenolics content extraction was performed by using the ionic liquid based microwave-assisted extraction (IL-MAE) method with some extraction parameters, including extraction time, microwave power, ratio liquid-solid, and ionic liquid concentration. The yields of total polyphenolic content were examined using a microplate reader 96 well method, and the extraction mechanism was analyzed using scanning electron microscopy (SEM). Results: The results showed that the effect of ionic liquid on the yield of total polyphenolics content, including 18.287 μg GAE/g (0.7 mol/l [BMIM]Cl concentration, 14 ml/l liquid-solid ratio, and 270 Watts microwave power for 10 minutes), and 15.734 μg GAE/g (0.7 mol/l [BMIM] Br concentration, 14 ml/l liquid-solid ratio, and 270 Watts microwave power for 15 minutes), whereas the SEM demonstrated the extraction mechanism with significant physical changes in matrix sample after treatment using different solvents. Conclusion: Application of green chemistry principles using an ionic liquid as a green solvent for the polyphenolic extraction of P. pellucida herbs to be rapid, easy, and efficient.

    Key words: Peperomia pellucida (L.) Kunth, total polyphenolic content, ionic liquid-based microwave-assisted extraction, 1-butyl-3-methyl imidazolium bromide, 1-butyl-3-methyl imidazolium chloride.

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