Solubility and Dissolution Enhancement of Meropenem by Nano Suspension Approach

    Published on:July 2017
    Journal of Young Pharmacists, 2017; 9(3):429-435
    Original Article | doi:10.5530/jyp.2017.9.84
    Authors:

    Srinivasa Kumari Chirumamilla1, Uma Devi Padasala2, Haritha Aravally2, Lavakumar Vuppalapati3, Sowmya Cherukuri2*

    1OTPRI, Jawaharlal Nehru Technological University Ananthapur, Anathapuramu, Andhra Pradesh, INDIA.

    2Raghavendra Institute of Pharmaceutical Education and Research, K.R. Palli cross, Near S.K. University, Anathapuramu, Andhra Pradesh, INDIA.

    3Arulmigu Kalasalingam College of Pharmacy, Anand Nagar, Krishnankoil, Srivilliputtur(Tk), Virudhunagar, Tamil Nadu 626126, INDIA.

    Abstract:

    Objective: To prepare and evaluate the suitable nanosuspensions of Meropenem (BCS-IV drug) to increase its solubility and dissolution. Methodology: The meropenem nanosuspensions were prepared by emulsification solvent evaporation technique by applying ultrasonic energy through probe sonicator, where the organic phase of drug solution in methanol was emulsified in aqueous phase containing hydroxy propyl methyl cellulose as solubilizer and sodium lauryl sulphate as stabilizer. The prepared nanosuspensions were characterised for particle size, zeta potential, surface morphology by SEM, drug excipient compatibility by FTIR and DSC and conducted in-vitro drug release studies. Results: Results showed that the prepared nanosuspensions were having particle size range from 1 to 1000nm and the zeta potential from -10 to -20 mVs. Scanning electron microscopic pictures revealed that the obtained nanosuspension particles were spherical in shape with surface smoothness and in-vitro drug release studies notified that the prepared nanosuspensions showed increase in solubility and dissolution of meropenem when compared with the pure form. Conclusion: The nanosuspensions of meropenem could be successfully prepared and can be concluded that the nanosuspension formulation is a promising approach to increase the solubility and dissolution of BCS-IV drugs like meropenem.

    Key words: BCS-IV drug, Nanosuspensions, Solubility, Dissolution, Emulsification and Solvent Evaporation.

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