Self-nanoemulsifying Drug Delivery System (Snedds) for Topical Delivery of Mangosteen Peels (Garcinia Mangostana L.,): Formulation Design and In vitro Studies

    Published on:July 2017
    Journal of Young Pharmacists, 2017; 9(3):341-346
    Original Article | doi:10.5530/jyp.2017.9.68
    Authors:

    Liza Pratiwi1*, Achmad Fudholi2, Ronny Martien2, Suwidjiyo Pramono3

    1Department of Pharmaceutical Technology, Faculty of Medical, Tanjungpura University, Pontianak, INDONESIA.

    2Department of Pharmaceutics, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, INDONESIA.

    3Pharmacy Biology Department, Faculty of of Pharmacy, Gadjah Mada University, Yogyakarta, INDONESIA.

    Abstract:

    Objective: Purpose of this research was to get the optimum formulation of Self-Nanoemulsifying Drug Delivery System (SNEDDS) of mangosteen peels and to evaluate the permeation ability of active substances in the formulation. Method: Oil phase solubility of ethanol extract, ethyl acetate extract, ethyl acetate fraction, n-hexane fraction and residue of the mangosteen peels was tested with virgin coconut oil (VCO). The formulation was designed with a simplex lattice design using Design Expert software and the permeation was tested using Franz diffusion cell. Results: Based on the results of simplex lattice design methods obtained that the optimum formulation of SNEDDS was the composition of VCO, Tween 80, PEG 400 at a ratio of 1:6,95:2,05. The results of permeation test in vitro using Franz Diffusion cell indicated that the obtained SNEDDS ethyl acetate fraction of mangosteen peels that is 96.9223% higher than without preparation SNEDDS was 18,9426 % on hour-8. The optimum physical evaluation SNEDDS optimum values obtained involved drug loading of 125mg/5 mL SNEDDS, the transmittance value of 92%, emulsification time of 65 seconds, pH of 6.35, particle size 20 nm, zeta potential -12,40 and stable for three months. Conclusion: SNEDDS can improve the diffusion rate of mangosteen peels as a model poorly water soluble drug.Various samples of mangosteen peels were screened as candidates for SNEDDS on the basis of solubility of the active compound in oils, surfactants, and co-surfactants. Simplex lattice design methods can be used to obtain optimum formulation on SNEDDS.

    Key words: SNEDDS, Extract, Fraction, Mangosteen Peels, Simplex Lattice Design.

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