Objective: The main objective is to investigate the antidiabetic, antihyperlipidemic and antioxidant activity of methanolic extract of Cordia obliqua (MECO) in streptozotocin- induced diabetic rats. Methods: Acute toxicity study of MECO was carried out in rat to determine its dose for further study. Oral glucose tolerance test was performed to evaluate MECO on elevated blood glucose levels. Diabetes was induced in rats by administration of streptozotocin (STZ) (45 mg/kg) and it was confirmed 3 days after induction. The methanolic extract of Cordia obliqua (MECO) was orally given to the diabetic rats up to 21 days and the blood glucose levels were estimated at the end of each week. On 21st day of the experiment, rats were sacrificed after the blood collection for the biochemical, antioxidants in kidney and pancreas was isolated for histopathological observation. Results: Acute toxicity MECO did not show toxicity and death up to a dose of 2000mg/kg in rats. MECO 200mg/kg and 400 mg/kg doses significantly (P<0.005) reduced blood glucose levels in OGTT. Both the doses MECO treatment significantly (P<0.005) increased the body weight, HDL by dose dependently when compared with STZ treated rats. Also, MECO treated rats significantly (P<0.005) decreased the blood glucose, SGOT, SGPT and ALP when compared with STZ treated rats. Normalized the lipid, antioxidant levels were reversed to near normal in diabetic rats treated with MECO. Conclusion: From the above results it was concluded that the plant extract having the ability of managing hyperglycemic and complication of diabetes in STZ induced diabetic rats. Hence this plant may be considered as one of the source for the isolation of new oral anti hypoglycemic agent.
Key words: Cordia obliqua, Diabetes mellitus, Streptozotocin, Oral glucose tolerance, Hyperglycemic.