In vivo study of tetraprenyltoluquinone, an anticancer compounds from Garcinia cowa Roxb

    Published on:April 2017
    Journal of Young Pharmacists, 2017; 9(2):296-298
    Original Article | doi:10.5530/jyp.2017.9.58
    Authors:

    Fatma Sri Wahyuni1*, Lim Siang Hui2, Johnson Stanslas3, Nordin Hj Lajis4 and Dachriyanus1

    1Faculty of Pharmacy, Andalas University, Kampus Limau Manis, Padang, West Sumatra, INDONESIA.

    2CARIF (Cancer Research Institute Foundation) MALAYSIA.

    3Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 43400 UPM, Serdang, Selangor, MALAYSIA.

    4Laboratory of Natural Products, Institut of Bioscience, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, MALAYSIA.

    Abstract:

    Objective: To investigate the in vivo antitumor effect of TPTQ against H-460 lung cancer cell lines in nude mice. Materials and Methods: Female nude mice bearing H-460 tumor at size approximately 5 mm in diameter were treated with a single intraperitoneal dose 800 mg/kg of TPTQ. The vehicletreated (10% tween 80) animals were used as control group. The tumor size and mice body weight were measured for 14 days. Results: Single treatment of 800 mg/kg of TPTQ displayed moderate antitumor activity against H-460 tumor xenografts as compared with vehicle-treated control. The mean time to reach RTV of 4 for vehicle-treated control group was 4.5 days whereas for TPTQ-treated (800 mg/kg) group was 9.5 days. Conclusion: The results showed that TPTQ slowed the tumor growth by 5 days. Thus, TPTQ may be considered as a promising compound in cancer chemotherapy.

    Key words: Tetrapreniltoluquinone, Lung cancer, Nude mice, H-460, Xenografts.

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