Peer-Reviewed · Quarterly

Journal of Young Pharmacists

Peer-Reviewed · Open Access

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Journal Impact Performance

Impact Factor

0.700

2-Year Metric

As per Journal Citation Reports 2026

Category: Pharmacology, Toxicology and Pharmaceutics > Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Sources: Journal Citation Reports from Clarivate, 2026 release.

The Journal of Young Pharmacists (JYP) is a peer-reviewed, open-access journal and a leading source of information on developments and trends in pharmacy education, practice and research. It publishes original research articles, reviews, case reports, short communications, letters, editorials and commentaries on a broad range of topics relevant to pharmacy students, educators, researchers and practitioners, from basic research to clinical studies.

Editorial board

Dr. S. Parasuraman, M.Pharm., Ph.D.
Editor-in-Chief
Faculty of Pharmacy, AIMST University, Jalan Bedong–Semeling, 08100 Bedong, Kedah Darul Aman, Malaysia
Dr. Chakradhara Rao Satyanarayana Uppugundur
Associate Editor
Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India
Dr. Madhavrao C
Associate Editor
All India Institute of Medical Sciences (AIIMS), Mangalagiri, India
Dr. B. Rajalingam
Associate Editor
Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore, India
Christapher Parayil Varghese
Associate Editor
Independent Researcher, Australia
Dr. Raveendran R
Editorial Board Member
Department of Pharmacology, JIPMER, Puducherry, India
Dr. Ashok Kumar Tiwari
Editorial Board Member
CSIR-Indian Institute of Chemical Technology, India
Dr. Srinivasa Reddy Bonam
Editorial Board Member
CSIR-Indian Institute of Chemical Technology, India
Dr. Md. Wasimul Haque
Editorial Board Member
Ranchi College of Pharmacy, Hatia, India
Dr. Tauqeer Hussain Mallhi
Editorial Board Member
Jouf University, Sakaka, Saudi Arabia
Dr. Srisailam Keshetti
Editorial Board Member
Satavahana University, Karimnagar, India
Emilio Russo
Editorial Board Member
Magna Grecia University of Catanzaro, Catanzaro, Italy

Editors' Choice · Review Article

Drug-Resistant Tuberculosis at the Crossroads: Molecular Insights and Next-Generation Therapeutics

Lingaraj Kariyaplar Marulasiddappa, Abhishek Pete Nagaraj, Purushotham Karadigere Nagaraju

Tuberculosis (TB) growing prevalence of drug-resistant strains Mycobacterium tuberculosis, it continues to major worldwide disease and a major public health concern. Emergence of Extensively Drug-Resistant (XDR-TB), Multidrug-Resistant (MDR-TB) tuberculosis has confounded disease management globally and dramatically decreased the efficacy of traditional anti-tubercular therapy. Drug resistance mainly occurs through genetic mutations, improper drug usage, poor patient compliance, prolonged treatment duration, and activation of resistance mechanisms such as efflux pumps. They play an important role reducing intracellular drug concentration, thereby decreasing therapeutic efficacy and promoting multidrug resistance. This review summarizes the pathogenesis of tuberculosis, mechanisms of anti-tubercular drug resistance, and the contribution efflux pumps resistant TB strains. It also highlights current diagnostic approaches, including molecular and phenotypic techniques used for early detection of resistant tuberculosis. In addition, emerging therapeutic strategies such as efflux pump inhibitors, novel anti-tubercular agents, combination therapy, are discussed as promising approaches for overcoming drug resistance. Despite recent advances, challenges including prolonged treatment duration, adverse drug reactions, treatment failure, and limited diagnostic accessibility continue to affect TB control programs. This emphasizes the importance of early diagnosis, effective therapeutic strategies, and continued research to combat drug-resistant tuberculosis and reduce its global burden.

Read Full Text PDFDOI: 10.5530/jyp.20260061